Lymphocytosis did not occur, nor did hypoglycemia. Effects that may have been due to vaccine pertussis toxin were not found. Persistent crying was associated with painful local reactions. The children with seizures had a high rate of personal and family histories of seizures, and 90% had documented fevers (> or = 38 degrees C). Sixty children experienced severe reactions within 48 hours of DTP immunization: 32 children had seizures only, 14 subjects had hypotonic-hyporesponsive episodes, 2 subjects had fever > or = 40.5 degrees C only, 4 subjects had persistent crying > or = 3 hours, 6 children had seizures and fever > or = 40.5 degrees C, and 2 children had persistent crying and seizures.
WHOOPING COUGH VACCINE AFTER EFFECTS FREE
Serum was assayed for active pertussis toxin, both in free and immune-complex masked states.
Blood was collected for complete blood cell count with leukocyte differential count, serum chemistry measurements, and insulin and glucose values. Follow-up examinations were performed 1 month later.
Some comparisons were made between children with DTP vaccine-associated seizures and a comparison group of children experiencing febrile seizures unrelated to immunization.Ī history and physical examination were performed. Severe reactions included encephalopathy, persistent crying > or = 3 hours, hypotonic-hyporesponsive episodes (collapse episodes), fever > or = 40.5 degrees C, or seizures. Prospective, referral-based surveillance.Ĭhildren experiencing severe reactions within 48 hours of DTP immunization and evaluated within 24 hours of the reaction. To learn more about the causes of and risk factors for severe DTP vaccine reactions, children experiencing severe DTP vaccine reactions were studied. Large doses of pertussis toxin cause hyperinsulinemia and hypoglycemia as well as leukocytosis with a predominant lymphocytosis in animal models.
Active pertussis toxin in DTP vaccine has been proposed to cause severe DTP vaccine reactions. The pathophysiology of severe reactions to diphtheria-tetanus-pertussis (DTP)vaccine is not well understood.
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